Hyaluronic Acid and Niacinamide: Can You Mix Together?

If your skin is dry, dull and you need to improve the overall aspect of your skin, You can mix Hyaluronic acid and niacinamide.

If you want a rejuvenated skin, minimizing lines and other signs of aging as a bonus, keep on reading.

Hyaluronic Acid and Niacinamide may be what you are looking for.

Can You Mix Hyaluronic Acid And Niacinamide Together?

Hyaluronic acid and niacinamide are both water-based treatments that complement each other’s hydrating effects.

You can layer up hyaluronic acid and niacinamide together. 

One of the best ways to do that is to apply hyaluronic acid on dry clean skin to then add niacinamide.

If you want to mix them together, there are also many products that mix hyaluronic acid and niacinamide.

For example: 

  • Olay Regenerist MAX Hydration contains hyaluronic acid and niacinamide that treats redness, dry spots and fine lines 
  • Skin Inc. Vitamin B3 Serum contains glycerin, and hyaluronic acid treats blemishes, sagging skin, improving skin texture.

We will talk about more products that contain Niacinamide and/or hyaluronic acid later in this article!

Mixing Hyaluronic Acid and Niacinamide Quick Tip

You can use products that have niacinamide and hyaluronic acid already mixed in their composition, such as cleansers, etc.

But a good idea for possible quicker results is to use separate products and layer them up.

For example, we recommend The Ordinary Hyaluronic Acid and The Ordinary Niacinamide.

Note: Keep on reading for more details on how you can benefit from the combination of niacinamide and hyaluronic acid.

Who Can Use Hyaluronic Acid And Niacinamide together?

Who Can Use Hyaluronic Acid And Niacinamide together?

Hyaluronic Acid and Niacinamide are indicated to all skin types. 

Initially, Mixing hyaluronic acid and niacinamide can be powerful for skin hydration, restoration, and rejuvenation. 

If your skin is dry or overly dry, you can definitely try mixing hyaluronic acid and niacinamide together.

Oily skin can also take advantage of these two ingredients when combined with other products designed for these specific conditions.

Oily and acne-prone skin can benefit too, as hyaluronic acid takes care of hydration, niacinamide can control sebum.

When skin is hydrated and sebum is controlled, your skin will more likely not produce acne. 

The result is a skin you love.

If you have a combination and sensitive skin, you will also notice great results by continuous use.

Benefits Of mixing Hyaluronic Acid And Niacinamide Together

Benefits Of mixing Hyaluronic Acid And Niacinamide Together

Initially, Mixing hyaluronic acid and niacinamide can be powerful for skin hydration, restoration, and rejuvenation. 

Hyaluronic acid and niacinamide are both water-based treatments that complement each other’s hydrating effects.

I will not talk about technical stuff (even though this is very important), but our intention here is to give a review from the user’s perspective.

For this reason, we are gonna skip all the technical parts, and jump to the benefits it can bring to us.

But there are more benefits you can take advantage of, by mixing niacinamide and hyaluronic acid.

In addition to skin hydration, both niacinamide and hyaluronic acid can provide an extra boost on collagen and elastin stimulation.

According to research conducted by Prof. Dr. Bukhari, Muhammad, Khan, Sohail on the International Journal of Biological Macromolecules, hyaluronic acid can be used alone or in combination with other co-agents.

The results are collagen and elastin stimulation and face volume restoration. 

Mixing hyaluronic acid with some co-agents can leave skin tighter, improving elasticity and reducing signs of aging. 

“Improved skin hydration, collagen, and elastin stimulation, and face volume restoration. HA, alone or in combination with lidocaine and other co-agents, showed promising efficacy in skin tightness and elasticity, face rejuvenation, improving aesthetic scores, reducing the wrinkle scars, longevity, and tear trough rejuvenation” (Bukhari, S. N., Roswandi, N. L., Waqas, M., Habib, H., Hussain, F., Khan, S.,2018).

How To Use Niacinamide and Hyaluronic Acid Together?

How To Use Niacinamide and Hyaluronic Acid Together?

You can experiment with Hyaluronic Acid and Niacinamide in different ways and see what works best for you.

For example, you can choose a cosmetic such as serum or moisturizer that contains both Hyaluronic Acid and Niacinamide.

You can also use hyaluronic acid in your morning routine and niacinamide in your night routine.

Layering Hyaluronic Acid And Niacinamide

If you want you can layer Hyaluronic Acid And Niacinamide, adding it to your morning and night routine.

Here’s a way to Niacinamide and  Hyaluronic Acid:

  • Cleanse your face with your favorite cleanser
  • Dry your face and add hyaluronic acid serum for hydration
  • Gently tap tap tap your face to fix the product and wait a few seconds
  • Apply niacinamide serum for sebum and pore control
  • Gently tap tap tap and wait a few instants
  • Seal everything with a moisturizer that’s indicated to your skin type
  • Apply sunscreen ( for the morning routine) 

Why Should I Apply Hyaluronic Acid Before Niacinamide? 

As you have noticed by far, hyaluronic acid and niacinamide are safe to be used together, right? 

Now you should be wondering why it is a good idea to apply hyaluronic acid before niacinamide.

The reason for this is that once your face is cleansed, applying hyaluronic acid will take care of the hydration you need.

Then, you can reinforce this hydration with niacinamide that will also make sure to control the oils from the skin. 

Can I use Hyaluronic Acid and Niacinamide Everyday?

Yes, you can use Hyaluronic Acid and Niacinamide every day, adding them up to your day and night routine. 

Just make sure your face is super clean and that you are using high-quality products that will actually make the difference.

How Long Does It Take To Start Seeing Results?

If your skin is normal and doesn’t have any concerns, you may start seeing results of improved skin texture more or less, after 15 days.

Now, If your skin is too oily, it may also take around two weeks to start seeing the effects of oil control.

Have dry skin? You may start to notice improvements in skin moisture in the first week or so.

If your skin is severely dry, it may take longer, but around three weeks, and you may need to consult a doctor for proper treatment.

Talking about acne scars, redness, and hyperpigmentation, you should wait a little more to start seeing actual results.

Even though you may experience quick improvements in skin texture, you would still need to wait around three to four weeks to start seeing more advanced improvements.

All this, of course, depends on your skin situation, the less aggravated is your situation the quicker it is to see results.

However, if your skin is facing severe problems, it is always indicated to look for a dedicated medical prescription. 

Breaking Down ​​Hyaluronic Acid And Niacinamide

So far we have had an overview of what happens when you mix Hyaluronic Acid and Niacinamide.

Now, it’s interesting to break down what these two items will do for our skin individually.

If you can think about what Hyaluronic Acid and Niacinamide can make individually, you can have a better idea of how they can potentialize each other.   

What Is Hyaluronic Acid

Hyaluronic acid has been used in the cosmetic industry in many different forms.

It is not difficult to find a variety of serums, creams, injections, and hair treatments that contain hyaluronic acid.

But why is hyaluronic acid so required by cosmetics? 

Because this has a super-powerful hydrating effect and many other benefits for the skin.

  • Its structure has the ability to hold approximately 1000 times its weight of water (Bukhari, S. N., Roswandi, N. L., Waqas, M., Habib, H., Hussain, F., Khan, S.,2018).
  • Benefits include skin hydration, smoothening, rejuvenation and regeneration (Bukhari, S. N., Roswandi, N. L., Waqas, M., Habib, H., Hussain, F., Khan, S.,2018).

Empirical research has been proving that cosmetic products that are rich in HA (ex. Gels, creams, lotions, serums, and so on) are efficient and can bring the following benefits to your skin:

  • Anti aging treatments (wrinkle reduction, nasolabial folds, etc)
  • Skin softness and hydration
  • Collagen stimulation
  • rejuvenation
Hyaluronic acid and niacinamide

Bukhari, S. N., Roswandi, N. L., Waqas, M., Habib, H., Hussain, F., Khan, S.,2018).

When the skin is hydrated you can expect to find visible improvements in wrinkles and other signs of aging. 

Having this in mind, your skin will not only benefit from hydration but consequently, it will be improved in texture and look rejuvenated.

According to this other study, daily external injury such as pollution, weather combined with the normal process of aging, makes our skin lose moisture.

As hyaluronic acid has an immense capacity for retaining water, it can be very effective in delaying signs of aging.

Researchers say there is an association between aging and loss of skin moisture. 

Guess what is the key molecule that’s responsible for maintaining skin moisture?  

Hyaluronic acid is the key molecule related to our skin moisture (Baumann L. Skin aging and its treatment. J Pathol. 2007).

Having this in mind, we should consider having this in our skincare routines ASAP. 

I could spend lines and lines writing about many different studies that cover the benefits of hyaluronic acid for the skin.

But the basic principles are covered here so far. 

Let’s now move to our next little friend, Niacinamide, and how we can use this for our benefit. 

What is Niacinamide

Now that you know that hyaluronic acid is great for hydration and will be your friend while preventing signs of aging, let’s talk about Niacinamide.

Niacinamide, also known as vitamin B3, is an essential water-soluble vitamin (P. Matts, E. Oblong, DL. Bissett, 2016), can bring many benefits to the skin including :

  • Sebum control and acne prevention 
  • Anti aging and fine lines reduction
  • Collagen boost

This study performed a topical experiment with 50 women with clinical signs of fine lines, wrinkles, poor skin texture, and spots.

They applied 5% niacinamide on these women for 12 weeks and the results were significantly satisfactory (Bissett, Donald & Oblong, John & Berge, Cynthia, 2005).

They concluded that continuous use of niacinamide can reduce fine lines, wrinkles, spots, redness, improve skin texture and elasticity.

Apart from topical use, you can also find niacinamide in ailments such as milk, eggs, green vegetables, and grains.

So having a balanced nutritional plan that contains these products may be a good idea as well if you want to benefit from niacinamide.  

But the topical use is still one of the best ways to use niacinamide as it provides quicker absorption.

Here are some other benefits of using niacinamide on your skincare routine:

  • Hyperpigmentation treatment /skin brightening
  • Auxiliares in ceramide growth creating a skin barrier that retains moisture
  • Helps with keratin building
  • Pore minimization 
  • Reducing inflammation
  • It’s antioxidant (combats radical free)

Comparing Hyaluronic Acid vs. Niacinamide

You know that you don’t have to choose one over another as you can combine hyaluronic acid with niacinamide altogether.

However, let’s establish a parallel here, where we can put one beside the other so we can understand them even more.

For this, take a look at the comparison table below with similarities and differences:

Hyaluronic AcidNiacinamide
The Body Produces it 
Attracts and Retains skin moisture/ water
Sebum /Oil-control
Anti-aging / reduces wrinkles 
Vitamin B3
Improves elasticity 
Boost collagen 
Improves skin texture 
Treats hyperpigmentation redness

As you can see often, both Hyaluronic Acid and Niacinamide complement each other, but there are still similarities and differences.

Taking a look at their main similarities, the bottom line is:

  • They are both very hydrating and rich with anti-aging properties
  • Suitable for all skin types

 Now, taking a look at their main differences, in a nutshell, we have:

  • While hyaluronic acid is produced by our own organism, niacinamide will be acquired from a rich diet
  • Hyaluronic acid is still the winner on hydration, so if your skin is super dry you should know skip a hyaluronic acid treatment
  • If you want to treat hyperpigmentation and redness, niacinamide can be a better ally for brightening than hyaluronic acid
  • For even skin tone, niacinamide will also be a better option over hyaluronic acid.

But, as you have learned, you don’t have to choose one or another. 

Just implement both products on your skincare routine and have each one potentialize your routine.

The results will be a wonderful skin complexion, bright, hydrated, with greater texture and rejuvenated skin.

Best Hyaluronic Acid and Niacinamide Products

If you are looking for great recommendations of products that contain Hyaluronic Acid and Niacinamide, we gotcha.

 As I mentioned before, you can choose a cleanser or whatever product that contains both hyaluronic acid and niacinamide together in the composition.

Or you can buy them separately and layer them up, which is really cool.

Or you can do both ways to work better for you.

For example, if you suffer from acne, you can buy the  CeraVe Acne Foaming Cream that among other components, contains hyaluronic acid and niacinamide.

Then You can try layering the ordinary hyaluronic acid and niacinamide, which are two different products that you buy separately.

If you have dry skin you can get one of cerave’s cleansers and then proceed with the ordinary skincare routine.

For sensitive skin, for example, you can try one of Cetaphil’s cleansers and proceed with your normal skincare.

Ok, enough for now, and let’s jump to the winning products of this edition.

You are not going to regret using them, because they are not only great but really affordable too!

The Ordinary Hyaluronic Acid 2% + B5

The Hyaluronic Acid 2% + B5 is vegan, cruelty-free, and will leave your skin super hydrated for sure.

This is a great humectant serum that you can use every day, in your morning and evening routine.

Many people said they will keep your skin looking fresh and hydrated. 

You will probably like how your skin will look smooth and improved over time.

If you are sensitive, this product should work great for you too, so it’s worth a trial. 

It is important to say that you should try it yourself because different skin types can react differently. 

Overall this is a great product but if blemishes, irritations, and breaking out occur, you should stop using it immediately.

The Ordinary | Niacinamide 10% + Zinc 1%

Now it is time to talk about The Ordinary | Niacinamide 10% + Zinc 1%.

This is a water-based serum as well, and you can apply it right after applying hyaluronic acid.

The Ordinary | Niacinamide 10% + Zinc 1% says this product helps you by treating skin blemishes and congestion.

It is highly indicated while treating acne scars, but anyone can benefit from it, especially oily skin folks.

If you have dryness on your skin, that means you should not use it? 

I guess you can still use and benefit from it because this product can also be a great collagen booster and will improve skin texture over time.

The way you can use The Ordinary | Niacinamide 10% + Zinc 1% is right after applying hyaluronic acid and before moisturizer.

If you prefer to use it alone, apply it on a clean face, and then proceed to apply a good moisturizer.

You can use it every day, in your day and night skincare routine.


Can you combine Hyaluronic Acid and Niacinamide together? 

In this article, you learned that yes you can combine Hyaluronic Acid and Niacinamide together, as they complement each other.

You also had a look at how to use Hyaluronic Acid and Niacinamide together to improve hydration and skin texture.

In addition, you also learned that they can also be important anti-aging agents in any skincare routine.

But not only that, but we also learned how to use them, and other benefits you can expect by using them.

We took a look at their main differences and I gave you a few suggestions of great products you can try out.

If you have any extra questions, please use the comments section below to send it and we will be happy to reply!


Until this moment, I haven’t placed any affiliate links in this article. I may change my mind in the future and start to use affiliate links for a couple of products, but you will be notified if I decide to do it.

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